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KMID : 0378019820250030109
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New Medical Journal
1982 Volume.25 No. 3 p.109 ~ p.114
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Double-Mind Investigation Comparing Bezafibrate and Placebo in Patient with Hyperlipoproteinemia Type IIb and IV
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Abstract
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The effects of bezafibrate on type IIb and IV hyperlipoproteinemia were investigated in 60 patients from Jan. 1981 to Nov. 1981 at Kyung Hee University Hospital. 200mg of bezafi￢brate were given orally three times daily for 4 to 6 weeks and the data were analized as follow with a double olind method.
1. In over all cases with hyperlipoproteinemia, the percentage change for TG with bezaf ibrate therapy amounted to -31%(p<0.005), for TC - 14% (p<0. 0025) and for HDL-choles￢terol +20%/(p<0-05).
2. In type IIb patients, the percentage change for TG with bezafibrate therapy was -33% (p<0.005), for TC -160o(p<0.005) and for HDL-cholesterol +290o(p<0.025).
3. In type IV patients, the percentage change for TG with bezafibrate therapy was -36% (p<0.005), for TC -11%(p<0-025) and for HDL-cholesterol +23-5%1(p<0-05)￢
4. Three patients experienced mild epigastric discomfort and nausea. These side effects were transient and disappeared within a few days spontaneously.
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KEYWORD
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